Yeast Display Antibody Discovery
At DuneX Biosciences, we specialize in yeast display–based antibody discovery and engineering, providing end-to-end solutions for biotech and pharmaceutical partners. Our advanced FACS-based selection platform enables rapid identification, affinity maturation, and validation of high-performing antibody candidates — reducing timelines and boosting discovery success rates.
Workflow Overview
Our streamlined yeast display discovery workflow integrates advanced automation, data analytics, and high-throughput screening to deliver validated antibody candidates rapidly and efficiently.
Package Pricing
Discovery Starter
$18,000
1 library (10⁷ diversity), 2 rounds FACS selection, binding validation by flow or ELISA.
6 weeks TAT
Affinity Optimization
$25,000
Affinity maturation with 3 additional sorting rounds and BLI kinetic analysis for top clones.
8 weeks TAT
Full Campaign (End-to-End)
$45,000
Custom library (10⁹ diversity) + up to 5 rounds FACS selection + NGS analysis + recombinant expression & purification deliverables.
10 weeks TAT
Turnaround: 6–10 weeks per complete discovery campaign
Deliverables: Top antibody sequences + binding data + enriched yeast clones
Applications: Therapeutic antibodies • Bispecifics • Dianostic reagents • Target validation
Core Services
Custom Library Construction
$8,000
Design and generate scFv or Fab libraries (immune, semi-synthetic, or naïve, 10⁷–10⁹ diversity).
FACS-Based Binder Selection
$5,000/round
Multi-round enrichment on target antigens using Sony SH800 / BD FACSAria; gating based on antigen-binding fluorescence.
Affinity Maturation
$6,000
Directed evolution through chain shuffling or error-prone PCR to enhance affinity and specificity.
Epitope Binning & Kinetic Screening
$3,500
BLI / SPR analysis to rank clones by binding kinetics and epitope diversity.
Sequencing & Bioinformatics
$2,000
NGS-based repertoire profiling, clone clustering, and sequence optimization report.
Recombinant Expression & Purification
$2,500
Small-scale antibody expression (E. coli / mammalian) and purification for validation assays.
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