DuneX yeast display antibody discovery solutions platform visual

Yeast Display CRO Solutions

Antibody discovery campaigns for decision-ready binders

DuneX Biosciences helps biotech teams discover and optimize sequence-verified scFv and VHH binders using quantitative yeast display, FACS enrichment, and practical follow-up development paths.

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Yeast display programs shaped around your target, assay, and next decision.

From first binder panels to evolved variants, each campaign is designed for ranked clones, sequence clarity, and decision-ready follow-up data.

Binder Discovery

Fast identification of sequence-verified scFv and VHH binders

Human scFv and VHH discovery powered by yeast display screening, quantitative flow cytometry, and iterative enrichment workflows.

Best for teams that need a practical binder panel quickly to support screening, validation, or go/no-go decisions.

DuneX-Nova™ Human scFv DiscoveryHuman scFv

DuneX-Nano™ VHH DiscoveryVHH

Which format should I choose?

Choose scFv for human-compatible discovery and standard antibody development paths.
Choose VHH for compact binders and access to challenging or recessed epitopes.
Run both in parallel when epitope diversity or backup coverage is critical.

Best Fit Scenarios

Fast-follow programs requiring rapid binder generation.
Multiple binders needed for screening, validation, or backup.
Benchmark antibody, ligand, or competitor binder available.
Difficult, conserved, small-protein, or membrane-associated targets.
Early programs needing quick go/no-go data before larger investment.

Inputs

Purified protein, Fc-fusion, bead-coupled target, peptide, or cell-surface target.
Biotin / streptavidin systems, direct fluor labeling, secondary detection, or custom assay formats.
Program goals such as blocking, internalization, epitope diversity, affinity tier, or species cross-reactivity.

Deliverables

Sequence-verified binder panel ready for downstream evaluation.
Ranked clone set with clear prioritization.
Round-by-round enrichment summary.
Screening-level binding curves and titration profiles.
Screening-level affinity tiering to support clone selection.
Recommendations for IgG, Fc, soluble VHH, or follow-up development.

Data Confidence

Quantitative flow cytometry-based screening.
Round-by-round enrichment tracking.
Internal controls to monitor specificity, background, and reagent binding.
Reproducible selection workflows designed for practical decision-making.

Affinity Maturation

Turn existing antibody hits into higher-performance leads

Focused diversification and high-stringency yeast display selection to improve affinity, off-rate behavior, specificity, and expression balance.

DuneX-Evolve™ Affinity MaturationOptimization

Methods

CDR-targeted diversification.
Focused mutational libraries.
Off-rate-driven selection.
Stringency ramps across selection rounds.
Expression versus binding optimization.

Best Fit Scenarios

Existing hit needs stronger binding or better potency.
Lead requires improved off-rate behavior.
Performance needs to be recovered after humanization or reformatting.
Specificity needs to be improved or background binding reduced.
Parent clone needs a ranked variant panel before downstream development.

Deliverables

Improved variant panel with measurable performance gain.
Ranked sequence set with comparison to the parent clone.
Parent-versus-evolved binding data.
Screening-level affinity and behavior profiles.
Recommended leads for downstream validation.

Program Outcome

Designed to rapidly convert initial binders into decision-ready antibody candidates.

Supporting Biotech Teams Worldwide from the San Francisco Bay Area

Share your target format, project goal, and desired binder profile. We’ll help map the fastest practical path toward a focused yeast display discovery campaign.